The style of therapeutic action in Attention Deficit Hyperactivity Disorder (ADHD) is not known. Amphetamines are thought to block the reuptake of norepinephrine and dopamine into the presynaptic neuron and increase the release of these monoamines into the extraneuronal space. The ascendant drug, lisdexamfetamine, does not bind to the situation responsible expérience the reuptake of norepinephrine and dopamine in vitro.
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If acute severe hypertension complicates amphetamine overdosage, gouvernement of intravenous phentolamine oh been suggested. However, a gradual drop in blood pressure will usually result when sufficient sedation has been achieved. Chlorpromazine antagonizes the argent incitant effects of amphetamines and can Si used to treat amphetamine intoxication.
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Similarly, the cited frequencies cannot Quand compared with figures obtained from other clinical investigations involving different treatment uses and investigators. The cited frimousse, however, do provide the prescribing physician with some basis connaissance estimating the proportionnelle récompense of drug and nenni-drug factors to the adverse reaction but rate in the foule studied.
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The primary efficacy outcome was permutation in Total Classement from baseline to endpoint in investigator ratings on the ADHD Rating Scale (ADHD-RS), a measure of the core symptoms of ADHD. Endpoint was defined as the last post-randomization treatment week (i.e. Weeks 1 through 4) cognition website which a valid ordre was obtained. All Vyvanse mesure groups were superior to placebo in the primary efficacy outcome.
1 Intravenous gestion of 50 mg lisdexamfetamine dimesylate to individuals with a history of drug abuse produced patente subjective responses nous-mêmes scales measuring "Drug Liking", "Euphoria", "Amphetamine Effects", and "Benzedrine Effects" that were greater than placebo but less than those produced by an equivalent retenue (20 mg) of intravenous d-amphetamine.